CROHN’S   DISEASE                                                  by  David w.Gregg

This Paper Is For Information Only. It Represents The Observations, Views And Opinions Of The Author, But Is Not A Recommendation For Treatment. Anyone Reading It Should Consult His/Her Physician Before Considering Treatment.

When the remedies were first discovered, only people with Crohn’s Disease tried them. However, since then some people with ulcerative colitis have tried them and found them to be equally effective.

I am not a medical doctor and thus do not attempt to treat people; but, in an effort to help a new friend, Barbara, who suffers from Crohn’s Disease (CD), I performed a literature search, and thought deeply about the disease. Within this process I identified two new potential approaches that I thought might be helpful. Neither approach had been used for CD before. I provided Barbara with the results of my search along with my first theory about how CD might be remedied. She discussed it with her physician. She told me that he said that he didn’t see how trying it would do her any harm. She had abdominal pain, which had lasted for more than three months with varying degrees of severity, even though she was under a doctor’s care and her disease was in partial remission. Barbara decided to try the suggested remedy. She was working half days because of the inflammation, went home at noon as usual, purchased the material at a health food store at minimal cost and applied it. Her abdominal pain was reduced to a mild sensitivity within an hour. That was in February 1995. She was able to return to work full time shortly thereafter. Her disease has been under control ever since then without other medications being required. She gradually recovered her full physical strength and general health, and has noticed no ill side effects from the remedy. She said that before this time she rarely had one good day a month. Shortly after starting the “treatment” she said she felt terrific and rarely had one bad day a month. Her disease management cost changed from approximately $5,000 per year (covered by insurance) with conventional medications, which did not work very well and had substantial negative side effects, to approximately $50.00 per year (no insurance coverage needed) with far better control of the disease and absolutely no negative side effects.

Since that time more than twenty other people with Crohn’s Disease and several with Ulcerative Colitis (UC) have chosen to try it. It seems to work equally well with both diseases. They purchased and applied their own material. Their reported success rate has been better than 90%. They have been able to discontinue other medications and enjoy freedom from abdominal pain and intestinal inflammation. Once it works for an individual, there are no cases of a person becoming desensitized to its benefits. It continues to work, with additional applications as needed, indefinitely. According to my theory, the remedy does not just block the pain, it stops both diseases by stopping the common process that causes the degeneration of the intestine.

The time span between my first learning about Barbara’s disease (I had never heard of Crohn’s Disease before) to my identification of the first projected remedy was three days. She tried it the next day and to my amazement she said it took effect within an hour. This relatively brief time to effectiveness has been repeated many times with many people. I have been told of pain relief time ranging from 20 minutes to four hours.

I should make it clear that I am not selling anything and have no financial interest in the remedies. My motivation is strictly humanitarian. I would simply like to contribute what I can to help eliminate the horrible suffering associated with these diseases.

I. Dimethyl Sulfoxide (DMSO) as a Remedy for Crohn’s Disease

In order to appreciate the profoundness of the remedy, which is deceptively trivial in appearance, I believe it is important not only to present the results, but also to take the reader through the technical reasoning I employed. I have a formal education in chemistry and chemical engineering and am now retired after spending more than 30 years performing research at a national laboratory. During that time I developed a personal fascination with the potential of nutritional supplements for helping a broad range of physical and mental problems. It started when I was on the board of directors of a youth home with 70 problem children (wards of the court) and wanted to explore possible approaches for helping the children. This gradually led me into making a serious study of nutrition, biochemistry, medical physiology and psychology and the interrelation between them. I was deep into studying textbooks and performing literature searches on Medline (on the Internet) when I first met Barbara. She was the secretary for the new group I had joined at the national laboratory. I found her to be an exceptionally pleasant person with an exceptionally serious, disabling illness. So, I told her that I would use the capabilities I had developed to try to find something that might help her. I was proud and shocked when the first suggestion I made, derived from my first technical analysis of the cause of Crohn’s Disease, was totally successful.

Upon starting the literature search I quickly discovered that the conventional treatment for CD used steroids or sulfa drugs with only moderate success. Failure of the steroids frequently resulted in the need for surgeries removing the damaged part of the intestine. Multiple surgeries eventually end with the need for an ileostomy or a colostomy where excretion of the feces is diverted through the abdominal wall and is collected externally in a bag for disposal. Many other treatments had been tried with little success. The attempts at different treatments seemed almost random, possibly because there was no clear understanding of the cause of the disease. Some believed it was an autoimmune disease, but the evidence for that was not conclusive.

I decided to take a more logically tight, systematic approach, as I would do with one of my typical research projects. This involved first postulating a damage mechanism, checking it against the literature to see if it survives, and designing what should be a logically tight treatment based on the assumed mechanism. In order for me to have any chance of success with my extremely limited access to almost anything sophisticated, I knew I had to approach the problem with a very different thought process than the elaborate research facilities had. The first thing I did was to mentally separate the primary, complex cause of the disease from the damage mechanism, which I hoped may not be so complex. I then focused on the damage mechanism, which I hoped would be more amenable to a simple solution. I reasoned that the damage mechanism was very likely hydroxyl radical attack on the intestinal cells. From reading the medical literature, I discovered that there was considerable evidence that this mechanism might be a primary cause of colon cancer. They are well known to have the capability of destroying cells through oxidative attack and I thought Crohn’s Disease might be another expression of their damage. A literature search identified more than 15 publications in the last five years in which the authors also felt this might be true.

In a previous Medline literature search I had done on DMSO, focused on evaluating its toxicity, I discovered not only a lack of toxicity but also that it had been measured to be a powerful antioxidant. The search over the previous five years of medical publications yielded 1117 abstracts describing instances where DMSO was used. Many of the abstracts openly stated that DMSO was a well-tolerated material, and there were no publications indicating any level of toxicity. DMSO had been used in a variety of medical applications, but never for Crohn’s Disease. One paper presenting results for a number of materials being tested for antioxidant activity, listed the compounds in order of antioxidant effectiveness and then added the statement that none of them were as effective as DMSO.

DMSO has another very important feature that distinguishes it from commonly used vitamin antioxidants. It will rapidly diffuse through the skin into the blood stream. (There is no need or advantage to taking it orally.) According to my initial theory, this is not just an application convenience, but an essential feature that would make it more effective in the treatment of CD than other antioxidants.

I reasoned that if the damaging hydroxyl radicals are generated inside the intestinal cells, the antioxidants will have to penetrate the cell membranes to get at them. Vitamin antioxidants can have a difficult time penetrating the membranes, which may explain why they are ineffective for treating CD. However, DMSO cannot be stopped by any membrane. That is why it can rapidly diffuse directly through the skin. Thus, only DMSO (and now a second material with a slightly different mechanism, Melatonin, which I will discuss below) would be able to penetrate the cell membranes rapidly and quickly enough to deactivate damaging hydroxyl radicals generated inside the cells before they do damage. I postulated that because of this very unique penetrating characteristic, only DMSO, and now Melatonin, might be effective in reducing the intestinal damage associated with Crohn’s Disease. If my theory is true, treatment with DMSO would also serve to illuminate the biochemical cause of CD.

With these thoughts in mind, I thought DMSO had a reasonable chance of helping Barbara with her CD. When I talked to her about it, she told me that she had owned horses for many years and was quite familiar with DMSOs frequent use in veterinary medicine. She felt it would be a safe thing to try, in small amounts, even though she was aware that its use for application to humans had been approved by the FDA only for the treatment of interstitial cystitis. She consulted her physician and he thought it could safely be applied topically. When Barbara started using DMSO she was working half days because she was trying to recover from repair surgery and the deterioration caused by a major relapse of her disease. She went home at noon, as usual, and bought some DMSO at a health food store. She applied “about a teaspoon full or less” to her abdomen. (The body location is not important!) She then went to an afternoon movie. An hour into the movie Barbara noticed that something was missing. Most of her abdominal pain was gone!

Shortly thereafter Barbara was able to return to work full time and was feeling “wonderful”. After this success, I am amazed at how many people then called me to find out about it. I discovered that this horribly painful, commonly fatal disease is very prevalent. I am thus compelled to write this paper in an attempt to get this information into the Crohn’s Disease and Ulcerative Colitis community so it can be further evaluated, and hopefully provide near-term, safe help.

If my theory is correct, DMSO does not stop the primary cause of Crohn’s Disease. It only stops the damage mechanism, very rapidly. Thus, DMSO may have to be used on a continuing basis. The people using it so far apply it only when they feel the onset of abdominal pain. The DMSO quickly stops the pain (and the intestinal damage process) commonly in less than one hour but it can take up to a few days of repeated application. One of the benefits of its rapid action is that it does not have to be taken in a preventive mode, and there are no withdrawal problems. This is in contrast to the steroid treatment, which takes several weeks to take effect and thus often has to be taken in a preventive mode, and where withdrawal must be done with great care. The natural course of Crohn’s Disease is to cycle between active and remissive states. The DMSO appears to prevent damage during the active state, and may be required sporadically during remission. It appears to be an extremely affordable remedy that a person can live with comfortably. I recently talked to Barbara and she said it continues to control her CD when it becomes active, but she had to use it only twice in the last year

II. Melatonin as a Remedy for Crohn’s Disease

Melatonin is well known as an effective, nonprescription sleeping pill. In the book “Melatonin” by Ray Sahelian, M.D., he references research done by Hardeland, et al. that states “Melatonin has been found to be the most potent physiological scavenger of hydroxyl radicals ever detected. Melatonin stops damage immediately and is more effective as an antioxidant than even vitamins C and E.” He also states that Melatonin has the advantage of being able to freely enter and permeate all parts of a cell.

Given the experience with DMSO helping Crohn’s Disease, upon reading this, it seemed reasonable to me that Melatonin might be another likely remedy for C.D. I brought this to the attention of Barbara and discovered that she had just started taking Melatonin to help her sleeping problems. She decided to stop using DMSO and see if the Melatonin would control her C.D. It seemed to work for approximately two months when she started to get a recurrence of abdominal pain. At this point she returned to using DMSO, which controlled the pain in its characteristic short time.

Since Barbara’s experience, many people have tried both DMSO and Melatonin and both have worked quite well. It is difficult to say if they would both work quite well on the same person because different individuals seem to have chosen one or the other approach and remained with it once it worked. There seemed to be one significant difference in that it appears that DMSO seems to take effect within an hour while Melatonin might take a week or so.

At this point approximately half of those trying this are happy with Melatonin and half with DMSO. It is difficult to say in advance whether DMSO or Melatonin will be the best approach for any particular individual. One of the most interesting points is that once an approach does work for an individual, it does not become ineffectual with time.

I want to remind people that this write-up is for information only and is not a recommendation for treatment. I strongly recommend that you discuss this with your physician and read the large amount of information that has been published about both DMSO and Melatonin before taking any action.

Proposed Biochemical Mechanisms for DMSO Mitigating Crohn’s Disease

The Proposed Biochemical Cause of Crohn’s Disease

I propose that the cause of Crohn’s Disease is oxidative attack on the intestine, and not an autoimmune attack. Specifically, the attack follows the Haber-Weiss reaction where ferrous ions catalyze the dissociation of biochemically-produced hydrogen peroxide into highly reactive hydroxyl radicals. The excessively high production rate of hydroxyl radicals then produces cellular damage in the intestine. The reaction goes as follows:

H2O2 + Fe(+2) = Fe(+3) + OH- + HO

hydrogen peroxide + ferrous ions react to produce ferric ions + hydroxyl ions + hydroxyl free radicals

This reaction is always taking place in normal cells and can play a constructive metabolic role by helping with the initial oxidation of fats in the peroxisomes. However, for people with Crohn’s Disease, it takes place to excess.

The Proposed Mitigation Mechanisms for Melatonin and DMSO

Melatonin

In the book “Melatonin” by Ray Sahelian he states that Reiter, one of the most active researchers on Melatonin, believes that it stimulates the enzyme glutathione peroxidase, one of the body’s most powerful antioxidants. The details of how this enzyme operates to remove hydrogen peroxide are discussed in many books on biochemistry, and won’t be reproduced here.

DMSO

Mechanism 1: DMSO can be readily oxidized to dimethyl sulfone. DMSO has one oxygen atom and dimethyl sulfone has two. In the presence of hydrogen peroxide it can be oxidized, picking up one oxygen atom, converting the hydrogen peroxide to water.

Mechanism 2: In the process of carrying out literature searches, I discovered a paper in which it was reported that DMSO increased the number of transferrin receptor sites displayed on the outer membranes of two standard cell cultures with a response time of approximately ten minutes. (“A Rapid Redistribution of the Transferrin Receptor to the Cell Surface of HL-60 Cells and K562 Cells upon Treatment with Dimethyl Sulfoxide Due to Slowing of Endocytosis” D. Vestal et. al., Archives of Biochemistry and Biophysics, Vol. 276, No. 1, Jan. 1990, PP. 278-284) This opens up the possibility of a surprise mechanism for DMSO mitigating Crohn’s Disease. Transferrin transports iron in the blood. It picks it up from the intestine and brings it to all the cells in the body that need it.

If we postulate that this same effect occurs when DMSO is applied to the body, it will increase the rate of transport of iron out of the intestine and to other cells in the body. The immediate effect will be to lower the iron concentration in the intestine, and thus lower the rate of production of hydroxyl radicals in the intestine via the Haber-Weiss reaction (catalyzed by iron) discussed above.

It is interesting to note that the measured response time of the cells is fully consistent with the rapid response CD people observe for DMSO mitigating their abdominal pain.

It is also possible to postulate additional, downstream effects.

1) The increased transport of iron will specifically increase its transport to the bone marrow. This could increase production of hemoglobin, reducing any anemia that might exist, which is common with people experiencing a CD inflammation.

2) In normal people, the absorption of iron into the blood from the intestine is actively controlled. If this active control mechanism is sensing on anemia or the lack of it, then (in its simplest conceptual form) the existence of anemia would result in increased iron absorption in the intestinal cells, and the reduction of anemia would have a corresponding reduction of iron absorption. Thus, if the application of DMSO resulted in reduced anemia, it would reduce the rate of absorption of iron (from food) into the intestinal cells while increasing its rate of removal from the intestinal cells by transferrin in the blood, resulting in a two-pronged approach to reducing the Haber-Weiss reaction.

The actual control mechanism for iron absorption is complex and only partly understood. One mechanism that has been demonstrated to regulate the transfer of iron across the mucosal-capillary interface is the synthesis of apoferritin by the mucosal cells. When the host requires little iron, a large amount of apoferritin is synthesized to trap the iron within the mucosal cells and prevent transfer to the capillary bed. As the cells turn over (within a week), their contents are extruded into the intestinal lumen without absorption occurring, thus excreting unneeded iron. When there is a iron deficiency, virtually no apoferritin is synthesized so as not to compete against the transfer of iron to the deficient host. Considering this mechanism, one could postulate that the existence of anemia may prevent the formation of apoferritin. This would result in an increase in free (active) iron ions in the mucosal cells. If this is combined with an ineffectual removal of them into the blood by insufficient transferrin transport capacity, these free iron ions could then be very active in the Haber-Weiss reaction, producing excess hydroxyl radicals, and resulting in cellular damage. DMSO would cause increased transferrin transport capacity, reducing anemia, resulting in increased production of apoferritin in the mucosal cells, reducing free iron ion concentration, and thus reducing the activity of the Haber-Weiss reaction and cellular damage.

A Research Effort to Carry Out Needed Controlled Studies

I would like to strongly encourage the performance of controlled studies to evaluate the DMSO/Melatonin approach to mitigating Crohn’s Disease and Ulcerative Colitis so as to place it on a sounder technical basis. The ultimate goal would be to satisfy FDA requirements to qualify one or both of them as approved treatments.

UPDATE, 11/99

I just received the following e-mail, which I found to be particularly relevant and which stimulated some additional thoughts that might be helpful:

The e-Mail:Subject: Melatonin & TNF concentrations

Sent: 10/31/19 2:35 AM Received: 11/4/99 5:18 PM From: CBerger338@aol.com To: krysalis@value.net

Dear Mr. Gregg.

I wanted to share with you some observations regarding the use of Melatonin for Crohn’s Disease. Since I have Crohn’s, I read with interest your several publications on the web regarding the use of DMSO & Melatonin for use with Crohn’s Disease.

I subsequently tried both & had little or no benefit from the DMSO, but did benefit from the Melatonin. I found a dosage of 1 MG., once a day at night worked best, and it took about a week to start to see some benefit. The benefit was a reduced level of pain, but most important, almost complete elimination of the diarrhea I had. It was a slow process, with improvement showing up each day.

So, I thank you for taking the time to get the word out about these two products.

I also have a science background, and started to think about how Melatonin was working. I subscribe to the Townsend Letter for Doctors & Patients. This is a magazine that is devoted to alternative medicine, but is very professional in their approach. In any case, in the current issue, 1999, #195, page 37 is an article by Dr. Alan Gaby regarding Melatonin. In the article is mentioned the fact that Melatonin is known to inhibit tumor necrosis factor (TNF). TNF is an important part of the inflammation process that your body uses to attack foreign substances. Now what is really interesting about this, is that it is a known fact that all Crohn’s patients have a very high level of TNF. Actually, the most potent recently released FDA approved drug for Crohn’s, is something called Remicade, made by Centacor. Remicade works by eliminating TNF and has been shown in many clinical trials to have a marked beneficial effect on Crohn’s. It would be very interesting to investigate if Melatonin is in fact eliminating TNF & if DMSO also works this way.

Again thanks for providing the Melatonin information since it has been a big help to me.Should you find out anything regarding TNF & Melatonin, I would love to hear from you.

Best Regards,

Chuck Berger

My Response/Comments/Thoughts: This e-mail caused me to revisit thinking about Crohn’s Disease, which I had not done in many months. I had the following thoughts.

PROPOSED TWO DISCRETELY DIFFERENT MECHANISMS FOR CAUSING CROHN’S DISEASE, DICTATING TWO QUITE DIFFERENT TREATMENT PROTOCOLS

The information presented in this e-mail is new to me. It introduces the possibility that there are (at least) two discretely different causes of Crohn’s Disease, each responding well to quite different treatment approaches, for very fundamental biochemical reasons. I have been long aware that there are those that respond well to DMSO and those that don’t. And the distinction is quite sharp. The question is why? And, can this understanding lead to more successful approaches to treatment?

1) Those that respond to DMSO:

In this case the primary trigger is anemia. The anemia signals the intestinal cells to convert more inactive iron to active, soluble iron so it can be transported to the bone marrow to produce more hemoglobin. However, there is a defective iron transport system, which allows the soluble iron to stack up in the intestinal cells. This catalyzes the Haber-Weiss reaction (to excess) causing a high rate of production of hydroxyl radicals, which in turn cause excessive damage to the intestinal cells. It also prevents the correction of the primary cause, the anemia. The DMSO enhances the iron transport, reducing the immediate attack on the intestinal cells, and promoting the more gradual correction of the anemia. Once the anemia is corrected, the Crohn’s Disease inflammation remains corrected, without the need for more DMSO, until the next incidence of anemia.

Transdermal application of vitamin B12 and folic acid in DMSO: For all those suffering from Crohn’s Disease and particularly this case, I would suggest that you read my Health Notes on Anemia, Vitamin B12 and DMSO. It would appear that dissolving vitamin B12 and folic acid in DMSO and applying it to the skin (transporting it in through the skin) would be a profound help. All with Crohn’s Disease have severely damaged intestines, greatly inhibiting vitamin B12 and folic acid absorption, which will cause anemia. The transdermal application will bypass this obstacle and bring the vitamins into the blood directly through the skin.

Could the anemia be caused by atmospheric nitrous oxide destroying vitamin B12 in the body, which in turn causes the Crohn’s Disease? See the Health Note on Vitamin B12.For this cause, one would expect that women would be the more vulnerable than men and would be more likely than to respond to DMSO.

2) Those that respond to Melatonin (or the drug Remicade):

In this case the primary trigger is a food allergy, or a “leaky gut”. Foreign proteins from foods manage to penetrate the protective layer of the gut, before the digestive enzymes break them down, and trigger an allergic/inflammatory response. (Such an immune reaction is commonly triggered by protein molecules and rarely triggered by carbohydrates.) The TNF plays a role in this response. It may actively cause damage, or simply be an indicator of the inflammation.

It is common for the body to invoke an inflammation response to foreign invaders, such as pathogens. (The immune system often sees large protein molecules as invaders, much like pathogens and reacts the same.) The inflammation response is the body’s approach to providing a very rapid defense, which is not highly specific. It is the initial emergency response to control the situation that provides time for a more specific defense to be developed. Because it is not very specific, it can also attack some normal cells, which get sacrificed in the process. In the extreme, the attack on normal cells becomes the dominant damage mechanism. Thus, it would give the appearance of an autoimmune disease, when it is really an inflammation response. This has led some researchers to conclude that Crohn’s Disease is an autoimmune disease when it really isn’t.

Consistent with this theory, it would appear that both Melatonin and Remicade have the ability to suppress this inflammation response as indicated by both of them having the capability of reducing TNF.For this cause mechanism one would expect an equal distribution between men and women.

APPROACHES TO PREVENTION

1. SELECTIVE DIET: This introduces another approach to prevention; selective diet. I am certain that this is not so new to many CD sufferers. However, I would like to draw attention to a recently published book “Eat Right 4 Your Type” by Dr. Peter J. D’Adamo, (1996). The underlying theory behind this book is that people with different blood types have different immunological responses to different foods. Each blood type has a set of foods that they are compatible with and a set that they are not. This is related to the evolution of the different blood types in times when different diets predominated. It also gets specific enough to allow an individual to take action. It may not be perfect, but it presents a good start, based on some scientific data.

The premise makes some sense, and it is right on the mark when addressing this proposed cause of Crohn’s Disease. I would thus suggest the people with this problem read this book and initiate your own experiments, refining the specific diet to meet your own specific biochemistry.

2. PREDIGESTING (HYDROLYZING) THE PROTEIN BEFORE CONSUMPTION: If the food-allergy/leaky-gut theory presented above is correct, and I believe it is, then proper food processing could eliminate the disease at its source, preventing it from ever happening. Thus, eliminating the need for any drugs.

First, it should be understood that a protein molecule must be relatively large to cause an immune response once it enters the blood. Protein molecules are composed of a long chain of amino acids connected together, with different protein molecules having different lengths and sequences. However, they are all constructed from the same 20 amino acids. These amino acids do not cause an immune reaction for at least two reasons: They are recognized as “self” and they are too small. If the protein molecules in the food are first disassembled into their individual amino acids before consumption, no immune response will happen when the resulting amino acids are transported into the blood from the intestine. Also, since they will still be the building blocks your body needs to make protein, their protein nutritional value will not be diminished. In practice, it is not necessary to decompose the protein molecules all the way to individual amino acids. The same effect can be achieved even if the decomposition still leaves some amino acids connected in small chains a few amino acids long (called peptides).

The process of disassembling the protein molecules is called hydrolysis. It is the exact reverse of the process your body uses to construct protein molecules from individual amino acids. In the construction process, one amino acid is connected to another by removing a hydrogen atom from one and a hydroxyl radical from the other. The hydrogen and hydroxyl radicals combine to form a water molecule and the free bonds on the amino acids unite, binding them together. This is repeated many times, adding one amino acid after the next, forming the protein molecule. The process is carefully controlled by enzymes that determine the rate of protein synthesis and exactly which proteins are synthesized.

Hydrolysis simply reverses this process. A water molecule is split and added back to the same bond locations, recreating the original free amino acids, and consuming the water molecule.

HOME METHODS FOR ACHIEVING HYDROLYSIS (PROTEIN DISASSEMBLY)

1. Digestive enzymes: Digestive enzymes catalyze this disassembly process in your intestine, making free amino acids that are then absorbed into the blood. Thus, consuming supplemental digestive enzymes with your food should help greatly and may be sufficient to reverse or control The Crohn’s Disease.

2. Boiling in water: Digestive enzymes will be slow to take effect in your intestine and thus may not be totally effective (in time). However digestive enzymes are not required to hydrolyze protein (or carbohydrate) molecules. If foods are boiled in water, hydrolysis will take place. In general, the longer the boiling, the greater degree the proteins are disassembled.

3. Crock Pot: A crock pot has been designed to allow one to keep foods close to boiling for many hours. This would be the next step towards further improving the protein disassembly process.

4. Pressure Cooker: The most effective approach achieving the greatest degree of hydrolysis would be to cook the foods in a pressure cooker. This allows the water to reach a higher temperature before it boils. Pressure cookers are well known to be able to greatly shorted cooking times, for the same reason. One could experiment with a pressure cooker for any particular food to discover how long it takes to hydrolyze the food to where its proteins no longer produce an adverse reaction.

I would suggest the following starting point: Start with a can of soup, add water and vegetables, and cook in the pressure cooker. The time of cooking required to obtain adequate hydrolysis of the protein is unknown. It is up to you to determine this. Thus, cook for a while. Cool down and try the soup. If you still have a negative, inflammation reaction, return the soup to the pressure cooker and cook some more. Repeat this until you no longer have an inflammation reaction. This will only have to be done a few times before you know how long to cook in the beginning.

I would also suggest including at least some soybeans in the list of added vegetables. They have been found to be exceptionally high in nutritional value.

Demonstration of Effectiveness?: I know a young woman (early 30′s) who has been a vegetarian for essentially her entire life. Her choice was not made as a matter of principal or belief, but rather she found that she had an almost violent negative reaction to eating any kind of meat. She got severe abdominal pains and intestinal problems. As part of her vegetarian diet she periodically tried to eat beans. However, the high protein content of the beans most often gave her considerable abdominal discomfort (not as much as meat). I gave her a pressure cooker and she started preparing her beans in it. The result was she no longer had the abdominal discomfort from eating them. She has found that melatonin is helpful, which is consistent with the theory.

Protein Sources in Foods:

There may be a misimpression that meats provide proteins and vegetables do not. This is not true. All living cells must have some protein molecules to perform numerous essential tasks. Meats have a high concentration of protein and vegetables have a much lower concentration. Depending on the vegetable, the protein may invoke an allergic response as severe as meats can evoke even though it is in much lower concentration. Thus, vegetables will have to be thoroughly boiled also.

Boiling vegetables is usually avoided because there is a common belief that vegetables are more nutritious raw or near raw. This may be true sometimes but not always. In fact, it has been reported that for some vegetables, cooking enhances their nutritional value. However, for people with Crohn’s Disease, eliminating the damage to the intestine, thus improving nutrient absorption, will outweigh any nutrient loss due to extensive cooking. The primary risk of loss is likely to be nutrients dissolving in the water and being dumped out. This could be minimized by consuming the water phase, or steaming the vegetables (for a long time). However, simple chemistry dictates that cooking the food in the liquid phase (instead of steam) predicts a more effective hydrolysis of the protein. The water is a reactant, not just a heat transfer agent, and simple chemistry predicts that as the reactant concentration increases, the production of the product (hydrolyzed protein) will go more to completion. The cook will have to work out the details. Taking the soup approach presented above solves this problem.

SOME FEEDBACK

I have discussed this basic cooking approach with a number of people with Crohn’s Disease as well as Irritable Bowel Syndrome (IBS). In every case the individuals have independently discovered that boiling vegetables for a long time will convert them from being irritating to their intestines to something that causes no problem. This is a small sample, but when it is combined with what makes technical sense, it warrants others trying it.

UPDATE, 11/99 SUMMARY

It is likely that there are two different causes of Crohn’s Disease, anemia and food allergies. The intestinal damage mechanism is quite different for each. It is also reasonable to expect these two damage mechanisms to be interactive. Once one starts, it is likely to initiate the other. Both can be addressed without drugs. Anemia can be addressed with transdermal B12 & folic acid in DMSO and food allergy can be addressed by pressure cooking foods. I would suspect that someone with Crohn’s Disease may want to do both at the same time.

Most importantly, these approaches address the primary cause of the disease, stopping it or preventing it from starting. They don’t just attempt to reduce the damage or pain while the disease continues.

UPDATE, 1/00

I just received this e-mail and was given permission to post it.

SubjectCrohns/Sparx Sent: 1/28/20 10:03 PM From: sally.spalding@ac.com To: krysalis@value.net

Dr. Gregg,

I spoke with you several years ago, in relation to Crohns Disease. I have been taking Melatonin for three years and have had no on-set of the illness since. I cannot even express how this has dramatically changed my life.

Yesterday, I received a note from a friend who had just been diagnosed with CD and quickly went home to look up your name and number. I sent her the link to your website today. I would also like to order some Sparx. Can you please contact me for sending instructions.

Thanks again for everything!

Sally  P.S. It was the melatonin that helped, did not have much success with the DMSO.

UPDATE, 7/00

I just received this e-mail and was given permission to post it.

Subject: I FEEL BETTER THAN I HAVE IN 10 YEARS Sent: 7/10/20 10:43 AM Received: 7/7/00 2:15 PM From: Adler, Adam, adam.adler@attws.com To: ‘krysalis@value.net’, krysalis@value.net

Dear David,

First of all my name is Adam Alder, and i am 22 and have had chrons for about 10 years, and i hate it. I have done prednizone which worked temporarily but the side effects were more than i could handle, eversince i have been on Asacal no side effects but still not verry useful. Just recently i was in Texas on business for 3 weeks and was having a bad flair up. blood, puss , diareah, pain, fever I was so sick, and sick and tired of being sick and tired. so I email my friend, just for a sholder to complain on. He wrights back, Im sick of you farting and complaining, I will find you the cure… ya right i think. withing 3 hours i have about 15 links to sites with info on chrons. Then he says I have a feelling this David guy is on the right track. Because all your body really is, is one big chemistry set. So that day I go out and buy DMSO and some melitonin…. Apply the DMSO ouch it burns and itches, oh well mind over matter, if it works anything is worth it.. 4 hours hmnm I feel better 8 hours wow when i push on my gut i do not fell the sores as much…. I take the melitonen and wake the next morning feeling better than i have in a long long time… so for the rest of that week I did the dmso and the melitonin. This was about 5 weeks ago and feel absolutly increadible absolutly no signs zero i mean, of the nasty guy named CHRON. All the plumbing is working perfectly. I contnue with the melitonin and do the DMSO about 3 times a week, I will continue the dmso for about one more month then i will go off of my asacal. well I cant thank you enough, I will send you an update in a month or so,

thank you for existing

ADAM ALDER

UPDATE, 12/00

ETWALD GOES: (The Netherlands) email: ed@onsdorp.nl

I have received a total of 8 seperate email’s from Etwald Goes over the past two months. He has Crohn’s Disease and upon reading my proposed use of DMSO to help mitigate it, he decided to do a thorough technical background search on the internet to try to independently evlauate its potential merrit. He progressed from an initial technical evaluation to a successful personal use. His technical analysis has continued thereafter. His accomplishments have been truly profound. They go far beyond what I will attempt to summarize here. However, very fortunately he has created his own web site where they are presented:

http://www.kalenderweb.nl/crohn/treatment.php3?groepid=1

I strongly urge all those interested to read it and contact him directly for further dialog. As one example I will present a copy of his last email:

Subject: Re: Missing : http://www.krysalis-sparx.com/antiox.htm, Sent: 12/19/20 5:21 PM, Received: 12/17/00 4:20 PM

From: Etwald Goes, ed@onsdorp.nl To: David Gregg, krysalis@value.net

Hi David,

Thank you for posting my site address on your page. I’ve been working on this the last couple of days, and I’ve found some really nice articles :Also, on my website I’ve posted all medical studies I’ve found regarding the DMSO theory. I think I can proof every aspect of your theory…I’ve found medical studies which confirm :

The increased amount of iron in intestines of Crohn’s and UC patients

The Haber-Weiss reaction, which creates hydroxyl free radicals, when catalyzed with iron

The hydroxyl radicals make the cells create Tumor Necrosis Factor Alpha !

The Hydroxyl free Radicals cause the inflammation in the intestines

DMSO is a Hydroxyl Radical Scavanger

DMSO increases the transport of iron OUT of the intestines, to the bone marrow

The last piece of proof is me.. All of my symptoms are disappearing.

I feel better than I have felt in the last 5 years !I’ve also found some alternatives, that also work like DMSO :

Desferrioxamine is also able to remove the iron from the intestines, and yes, it is also a radical scavenger.. Just like DMSO…And yes, it also stops the inflammation in the intestines !It’s on :

http://www.kalenderweb.nl/crohn/ga.php3?linkid=44 and :

http://www.kalenderweb.nl/crohn/ga.php3?linkid=55 Phase II trial of copper zinc superoxide dismutase (CuZnSOD) in treatment of Crohn’s disease.

Quote : We obtained 19/26 very good short term responses, and 82% good results on long term

Note: This is also almost the same success rate as with DMSO !It’s on :

http://www.kalenderweb.nl/crohn/ga.php3?linkid=56

Thanks for reading,

Ed,

UPDATE, 1/01

A Proposed Third Cause and Treatment for Crohn’s Disease

Many with CD have been helped by either DMSO or melatonin, or both. However, sadly, there are still those who are not helped by either. Why is that so? It makes me suspect that there is at least one more fundamentally different biological cause for Crohn’s Disease which would require a very different approach to treatment. I believe I know what it might be and how to treat it. This leads me to a different medical issue that I participated in helping in the past, autism, which is commonly associated with intestinal damage sometimes diagnised as Crohn’s Disease.

Brief Background: I do not have an autistic child and do not treat autistic children. However, in 1997 Bernie Rimland, director of the Autism Research Institute, (4182 Adams Avenue, San Diego, CA 92116) put me in contact with Victoria Beck of New Hampshire. She had recently discovered that secretin (prosecretin), commonly used to check pancreatic function in medical evaluations, appeared to have helped her autistic son, Parker when used in such an evaluation. However, the doctors would no longer provide the treatment. Over the following year I had numerous phone conversations with her, helping her develop a method for treatment that she could employ at home, and an understanding of the operative biochemistry. It led to a dramatic breakthrough in the treatment of autism, applying to a majority of the autistic children that have been treated. In the beginning, the word spread quickly among parents of autistic children and many decided to try it, long before it received acceptance by the medical establishment. Within a couple of years its success received considerable public recognition with a review on Dateline in October 1998, and a feature article on the front pages of both the NY Times and the Wall Street Journal, March, 1999. All this happened before the medical establishment accepted it. At this point I believe it still lacks FDA approval, but many doctors are using it successfully to treat autism.

Relevance to Crohn’s Disease:The best overall description I have found presenting an overview of the biochemistry of secretin is presented in the “Textbook of Medical Physiology” by Guyton & Hall, 1996, Published by the W.B. Sanders Company. The book presents the known effects of secretin, but does not address its recently discovered relationship to autism.

Briefly, secretin is an intestinal hormone that has a multitude of effects, but the best understood effect and possibly the one that best explains its benefit to autistic children is its influence on the digestive system. In normally functioning people, secretin is synthesized the cells of the duodenum and stored there as prosecretin. When the highly acidic food leaves the stomach and enters the duodenum the acidity causes the duodenum cells to dissassociate the prosecretin, releasing secretin into the blood. The released secretin then stimulates the release of a bicarbonate flush from the pancreas into the duodenum, as needed, which neutralizes the stomach acid. In addition, this same bicarbonate flush also transports the digestive enzymes, synthesized in the pancreas, into the duodenum. They are necessary for digesting carbohydrates, proteins and fats. There is a similar bicarbonate flush in the bile ducts that helps to transport bile into the duodenum. The bile is necessary for emulsifying fats, making them digestible.

A child lacking the ability to release secretin will have a multi-pronged attack on the digestive system. First, the unneutralized stomach acid will severely damage the intestine. Second, there will be a deficiency of digestive enzymes and bile to process food.

This results in the child having considerable intestinal pain and stools that contain obviously undigested food of all types. With such a damaged digestive system, the absorption of nutrients from the intestine is severely impaired. This lack of nutrients entering the blood could fully explain the deterioration of mental function associated with autism. When secretin (prosecretin) is infused, the first thing that happens is the intestinal pain vanishes and their stools turn normal, indicating an end to intestinal damage and improved digestion of food. With essential nutrition now getting to the brain, the presentation of autism diminishes greatly.

Can this process occur, producing intestinal damage without producing autism? A couple of years ago Bernie Rimland told me that recently there was a dramatic increase in the rate of both autism and CD in England. I told him that it wasn’t CD, but rather the normal intestinal damage that goes with this form of autism. However, more recently I wondered if it wasn’t just another cause for intestinal damage commonly diagnosed as CD, and thus was CD, which only sometimes progresses to autism.

Why would these have occur together? There appears to be considerable evidence that in some cases childhood vaccinations may have triggered the onset of autism, more specifically the rubella vaccination. If this is so, there may have been a bad batch of vaccine that was given widely and triggered both autism and CD without progressing all the way to autism.

If this is truly a third cause of Crohn’s Disease, it would be easy to see why DMSO and/or melatonin would not be effective treatments. It would predict that treatment with secretin (prosecretin) could be very effective. To my knowledge, this has never been tried.

Secretin vs. Prosecretin: I would suggest you read my discussion at the end of my health note on autism. I believe there is an important distinction between treating with secretin vs. treating with prosecretin. I discuss that there. Only prosectetin should be effective. Secretin should not work. Briefly, prosecretin is stored in the duodenal cells and releases secretin when it is needed, timed with the arrival of acidic food from the stomach. The secretin then quickly stimulates the pancreas and is rapidly removed from the blood. Otherwise it could overstimulate the pancreas at the wrong times. Infusion with secretin will overstimulate the pancreas, not timed with its need for acid neutralization and digestion. Infusion with prosecretin will result in the absorption of the prosecretin into the duodenal cells where it is then used, timed properly. This distinction has resulted in an ongoing debate questioning the effectiveness of the synthetic human secretin vs. the use of prosecretin extracted from pig duodenum.

Pig Duodenum Powder, Freeze Dried: In either case, this leaves a person seeking out prosecetin infusions which require a doctor. It may not be feasible to find a doctor willing to try this as a treatment for CD. However, there is another option presently being explored, the use of freeze dried pig duodenum powder in the diet. It is simply an organ meat, but this organ meat also contains prosecretin. The original secretin infusions in Victoria Beck’s son, Parker, were with material extracted from pig duodenum. They also continued to be the most effective infusions. I reasoned that freeze dried pig duodenum powder should still have the prosecretin in it most favorable state, as prosecretin, not secretin. It is a hormone so very little would be needed. Why not add the freeze dried pig duodenum powder to the diet. It is simply organ meat containing prosecretin in its best ant least expensive form (no expense of extraction). A couple of years ago I found a source of the powder — approved for human consumption and obtained a sample. However, the mother who was originally interested in trying it decided not to, so I stored it in my freezer. It took more than a year before I was contacted by the grandfather of the child who had a similar thought. He wondered why you couldn’t just feed pig duodenum to the child. I emailed him back with “I have finally found you”. He asked for the sample and the bottom line is the initial trial, adding a tablespoon/day to his diet had the child getting rid of his abdominal pain and his stools changing from having lots of undigested food into normal stools. He also became more alert. These are very early results, but they are what would be expected if the theory is right.

Relevance to CD: At present there may be some question as to how much this improved the autism, a difficult measurement, but the most objectively observed result was the reduction in abdominal pain and the normalization of stools. These are the most relevant observations as related to CD. If these results stand the test of time, and if this is truly one cause of CD, then adding freeze dried pig duodenum powder to the diet should be an effective, inexpensive, safe approach to managing that form of CD &endash; that does not respond to DMSO or melatonin.

ETWALD GOES (The Netherlands, email: ed@onsdorp.nl): Response to Update 1/01 Theory and the Presentation of a Fourth Proposed Cause for Crohn’s Disease along with its Treatment, and its Relevance to Autism.

Hi David,

A very interesting and revolutionary new theory ! It’s true that some people don’t react well to almost any regular treatment.

Another point of interest.. You might want to consider to read another book : “Breaking the Vicious Cycle” by Elaine Gottschall. This book explains how people can break the vicious cycle inside their intestines. In short, it’s like this :

Most intestinal mycrobes require carbohydrates for energy. When the host eats a lot of carbohydrates that can’t be digested, these carbohydrates remain in the intestines and will be used by the mycrobes for energy. The mycrobes start multiplying and start creating acids and toxins. These acids destroy the enzymes on the intestinal cell surface. These enzymes are essential for digesting (splitting the carbohydrates) before they can be absorbed. The host responds by creating excessive mucus as a defence against the toxins and acids. Because of this mucus, the food can’t be absorbed anymore. The cycle can be broken by eating a special diet, which only consists of specific carbohydrates. Only simple carbohydrates are allowed, like mono-sacharide (sugar found in fruit and honey). di-sacharide (table-sugar) is not allowed. Over time, the mucus will not be needed anymore and will vanish.. Food can be aborbed again.. Inflammation will stop. The toxins and acids created by the mycrobes get into the blood stream. The brain is not protected against these acids and starts to disfunction. After being on this diet for a week, lots of people notice that the brain-cloud starts to vanish. Many mental disorders are “cured” this way. Some people even get scars on their brain after having severe intestine inflammation a long time. In particular, milk-acid (lactic-acid I think) is very bad for the brain.

 

And now the parallel with your theory : Because the intestines are exposed to stumach acid, the mucus will start to form here also. As a result, this same vicious cycle is introduced. Acids will enter the bloodstream and start bothering the brain. Right now (after re-reading the testimonials on www.scdiet.org), I’m not sure anymore which treatment worked the best for me. A week before I started using DMSO, I also started this diet. In that week, my weight didn’t improve, but I started to feel a bit better. When I started using the DMSO, my energy level improved a lot and my weight was going up very rapidly. Maybe, my 5 kilo weight gain is due to a combination of the two treatments. It might be interesting to read the book, because it explains it much better than I can:

http://www.amazon.com/exec/obidos/ISBN=0969276818/goodbooksA/

Maybe, it would be nice to send an e-mail to Keith Reisman yourself (about the updated theory). He will be able to bring your theory to a wide audience of doctors/researchers/patients. Keith J. Reisman <kreisman@mindspring.com>

By the way.. I went to my physician yesterday and he was amazed to see me in such good health. I think he believes it might be because of the DMSO. Also I left him a copy of your crohn.htm and some medical studies I had found. He seemed very interested. I also got my blood test results. My inflammation was completely gone (no flaws in the blood results). It seems like I’m completely healed! Still I don’t feel like a 22-year old should feel. My energy level is still a bit too low. I hope this will get better over time.

You keep amazing me. I’m sorry there aren’t many more people like you around. Medical doctors are too narrow-minded and don’t “dare” to invent new theories. Also, I’ve sent a link about your new cancer treatment to a webmaster of a dutch alternative cancer treatment site. He has good success with treating his cancer by using a diet and supplements.. There are parallels with your theory. He was very interested and saw the parallel himself. I will try to write a dutch summary of your cancer treatment, so he can post it on his site. He will also put a link to your site there. His site is on : http://www.kanker-actueel.nl/index_e.html

Keep up the good work. Greetings from the Netherlands,

Etwald

Email Update from ETWALD GOES 1/22/01 (A reversal due to change of diet.),

The following email clearly demonstrates the importance of the dietary advise presented by Elaine Gottschall in her book “Breaking the Vicious Cycle”. I read it and found it to be a truly outstanding analysis of one cause of Crohn’s Disease presented along with the successful dietary treatment/solution. Everyone with Crohn’s Disease should read it. It clearly addresses one of the causes, and can only help with the treatment of the disease that might have another cause.

Subject: Combined Treatment,

Hi David: How are you ? Here it’s been rather cold for a couple of weeks. Today, all the snow and ice melted. It’s about 10 degrees celcius once again.. Much better ! Did you read my findings on melatonin ? I think the ultimate treatment for persons with (my type of) Crohn’s disease is this : A week ago, I thought : What the heck, let’s try some other foods again. I had been on the diet and I had used DMSO for about 6 weeks. At that time I felt real perfect. No single symptom was left of my disease. My energy level was also 100% again ! A week later (now), I discovered I had a lot more gas in my system, my energy level dropped, I couldn’t sleep that good anymore, and the mucus returned in my intestines. I think the bad bacteria were just asleep after not having anything to eat for a month orso. When I started eating wheat, sugar, etc, they started to eat once again and the digestion problems returned very quickly. Now, I’m back on the SCDiet once again.. I’m even on a more strict diet, because I seem to allergic to baking yeast (no problem, because it isn’t allowed in the SCDIet too), but I’m also allergic to cheese, tomatos, paprica, curry and some others. So right now I am on a diet which combines the DON’TS of the SCDiet with the DON’TS of my allergy diet.. It’s amazing to see how much fruit and vegetable I can eat without problems.. I eat salads the size of which the entire family would eat of normally. Everything is digested perfectly, and I think my condition will return to the condition a week ago in one or two weeks. I always thought the DMSO was the part of my treatment that put me in remission. But it seems like the SCDiet also has a lot of influence there. My new theory is the following: In the inflammated intestines, two vicious cycles are occuring. One is on a chemical level, which causes the inflammation to go on and on. This part should be taken care of by using DMSO, antioxidants or even regular medicine. (because DMSO is the strongest and has the least side effects, the choice is clear) In short : Inflammation : cells put H2O2 and O(-2) in the intestines –> O(-2) extracts the iron from the intestine cells –> H2O2 + Iron turn into Free radicals –> Free Radicals start destroying the intestine cells -> Iron transport system collapses –> Because of free radical damage, the inflammation gets worse –> More H2O2 and O-2 are produced –> Iron which is ingested can’t get out of the intestines –> Anemia –> Iron overflow in intestines –> Free Radical production gets very bad –> etc etc. The second vicious cycle is the one described by Elaine: Bad digestion –> Parasites Overgrow -> Parasites eat leftovers your intestines didn’t digest -> Parasites drop acids in your intestines -> acids destroy enzymes and cells -> intestines starts a defence line : mucus –> Mucus prevents any food from reaching the enzymes –> even more leftovers are left for the parasites –> more acid.. etc etc. By combining both treatments, I think the remission rate will be very high. If you don’t like DMSO, there also other alternatives : Antioxidants (vitamin c,e), Flavanoids (like in Green Tea), Iron Chelators, a large range of antioxidants.And ofcourse: prednison, which stops radical production by using steroids (heavy side effects) or ASA-5 asacol, which is a strong free radical scavenger..

I will be updating my website soon. I will also add the information about the secretin…

Ed, The Netherlands

My Response:

Etwald,

Your CD certainly did not damage your brain! Your melatonin discoveries amaze me. They are truly insightful. You are right. DMSO and melatonin are both noted for their antioxident properties and they both appear to be effective for reducing the effect of iron overload (each with a different mechanism). That is fascinating. The connection to MS is also profound.

I am both delighted and sad that you decided to run the test of the importance of Elaine’s diet. You have demonstrated it is certainly important for your particular cause of CD, and it would appear that it is more important than DMSO. If the mechanism that Elaine presents is the cause of your CD, you would not expect DMSO to be very effective.

I did talk to one parent who has a son with severe CD for the past 10+ years. She said that she had tried Elaine’s diet with him and it did not work. Thus, she is now going to try DMSO, melatonin and pig duodenum. We shall see what happens. I will let you know if she lets me know.

If the concept is correct that there is a number of quite different causes for CD, each needing substantially different treatment approaches, it would be profound to show that it is true. This should lead to people not just being diagnosed with CD, but being diagnosed with a particular form of CD requiring its particuar treatment protocol. I don’t think anyone treating CD is thinking along these lines now. It would be powerful to get a community of research people working the problem from this viewpoint.

David Gregg

UPDATE, 2/01 Valadation of Pig Duodenum for treating one form of Crohn’s Disease?

Emails from one individual indicating the use of pig duodenum for treating Crohn’s Disease is a promising option. The idenity of the author is not presented in order to protect her privacy &endash; at her request. Lets call her mother alpha for later identification. (email: motheralpha@yahoo.com). You can email her direct for updated information.

EMail-1 Sent: 1/1/01 7:23 PM To: krysalis@krysalis.net

I have been reading all your articles on the net recently – Been trying to find help for my 19-year-oldson who has Crohn’s. Would like to order SPARX and the Aerobic Boost for him. He is in a bad flare-up right now and has been on Immuran for three weeks so far. Intend to start him on Melatonin after his blood test tomorrow (Read where it might cause false results to show up on liver enzymes) Also want to try DMSO but can’t find it here. Any ideas where I might order a good quality DMSO on the internet? My son has only has two three-month remissions during the past 6 years. Been through all the prescribed medicines and are ready to go your route.

Need help.

Thank you very much

EMail-2 Sent: 1/4/01 10:33 AM To: krysalis@value.net

David,

Thanks for keeping me updated. Found DMSO, tried it on myself first just to see and no problems, but when we put some on my son, he broke out in hives at the site of application. Another weird outcome was that he never got the garlic taste although I did. He’s allergic to most foods and most inhalants and began allergy shots at 17 months old. Tried Elaine Gottschall’s diet on him when he was quite a bit younger and he either couldn’t or wouldn’t eat most of the stuff. Going to get the book out and look again though. Started him on Melatonin last Friday night. Hoping that’ll be the one for him!! He has been able to eat very little lately due to pain and nausea, but when he is able to eat some I’m going to pressure cook it. Will order that pig duodenum powder too if you feel it might help to try it now along with the melatonin. I’ll buy some — just go ahead and mail it too.

This immunosuppressant imuran is dragging him down and he seems worse than usual this time, so we’re desperate to help him. He’s miserable and along with all the rest of the Crohn’s symtoms, he’s CONSTANTLY fatigued.

Thanks for all your help.

EMail-3 Sent: 1/24/20 9:23 AM To: krysalis@value.net

Dr. Gregg,

Thought you might be interested in an update – As I told you before, my son broke out in hives in the area where we applied the DMSO, so we were afraid to use that again. However, he did start taking melatonin on Jan. 5, Sparx on the 8th and pig duodenum on the 12th. By the 13th he was feeling great energy-wise. Said he FELT BETTER THAN HE HAD IN 8 YEARS!

He was ALWAYS tired and lifeless and never left the house except to go to the various doctors. He’s 19 now, but he actually only went to school for maybe 8 months total from 7th grade through high school, always trying for a few months and being too sick and tired to continue. So he had homebound teachers come to the house for all of those years. He began his first semester of college last Fall, taking all his courses over the internet and was making it until he had to have a tonsillectomy in the later part of October. Immediately after that his Crohn’s began flaring even worse. He was supposed to go on campus to take his finals in December, but was physically unable to. He spent the day of finals in the ER with dehydration and pain. On that day he was put back on imuran and soon after, larger doses of prednisone. When I discovered your web page in late December, his symptoms at that time were diarrhea, pain, nausea, no energy, constantly tired, and pale with dark circles under his eyes.

On Saturday Jan. 13th he was feeling great with all the new energy and the constant pains had subsided. He was so energetic and excited and of course anxious to get out of here that he and his dad took off on a trip the next day. My son did all the driving (8 hrs. a day for two days) and he never got tired or crampy. He stayed with friends his age for a week and spent the whole time playing games on computers, sleeping just a few hours a night, and eating nothing but fast foods. My son had not been able to handle eating ANY fast foods for years, so he was enjoying the heck out of all of it. His energy level stayed up, the only outcome of the visit was that he got some mild pains after eating and diarrhea 3 to 4 times within an hour after each meal, but that was minor to him.

As soon as he started feeling so well, he began tapering himself off the imuran and prednisone, so he’s kind of done everything at once! He has never been able to get completely off prednisone before.

He just got back home yesterday and is still bouncing with energy. I have high hopes that with the proper diet he may get rid of the minor problems he still has. The fact that he went from as miserable as he was to the life he lived for the past week is purely amazing. It may seem strange to you that we immediately allowed him to do all that, but he’s been stuck at home and sick for so long that it made it impossible for us to turn down the one thing he has wanted to do for years.

EMail-4 Sent: 1/24/20 12:33 AM To: krysalis@value.net

Dr. Gregg,

The bottom line is this – THANK YOU!!!!!!!!!!!!!!! What you have done is purely amazing and we will forever be grateful to you for changing my son’s life! We and he were always optimistic throughout the years that he would get better and had tried many different things, but nothing ever showed any promise. Actually it was just a few weeks before I discovered your writings that we were really down about his future for the first time. It was the first time he had said out loud ” What’s the rest of my life going to be like if I stay like this?” We just couldn’t see an end to his health problems and were on the verge of thinking that it wouldn’t ever get better.

Now with the results he has had with the melatonin and pig duodenum and your Sparx, I truly believe that he is going to be able to be a completely healthy, normal college guy attending classes in person, getting out in the world, and getting a “life” back!

We owe it all to you. Thanks for putting yourself out and doing what you did. You’re a wonderful person!

EMail-5 Sent: 1/26/20 7:33 AM To: krysalis@value.net

Dr. Gregg,

You have a winner for sure! Yes, you certainly may post my emails on your web page. The testimonials on your web page were a major factor in us trying the DMSO and melatonin. Always before, when I would find testimonials it seemed that the people were selling the so called “cure” themselves. But it was obvious that you were genuine. I was even amazed that you didn’t discuss your Sparx supplement on your page. I happened onto that during another search.

In answer to your question, it’s hard to tell if it was just one or all of the items that helped him due to the times he introduced them. All I know is that he’s a new person and not about to discontinue any one of them.

He started taking 1 mg of melatonin on Jan. 5, 1 Tblsp. Sparx a day on Jan. 8, and 1 Tblsp. Pig duodenum a day on January 12th. He mixes the Sparx and pig duodenum together in grape juice each day. I remember he was feeling good by the 11th, but the “Great” wasn’t until the 13th, when he went to a restaurant and ate a hamburger and fries with no ill problems after. He hadn’t gone out to eat for years because it wasn’t worth the pain it caused. While he was out of town that week he upped the melatonin to 2 mg a night and has stayed on that dosage since. Now that he’s back home, his diarrhea and ALL pain has stopped. He still is having to go to the bathroom too often, so we’re trying Bentyl, which hopefully will take care of that.

I’m of the belief that the pig duodenum is the factor that is allowing him to eat all his former forbidden foods.

His list of offending foods was so lengthy that he has spent several months at a time living on nothing but potted meat and soda crackers, which was always the only thing he could tolerate. Even that hurt, but not as much. He couldn’t even tolerate Ensure, which is the thing that most people with Crohn’s fall back on. He would get desperate and try it once or twice a year, but always with too much pain and nausea from it.

After reading about the autistic children you helped and how some people believe the MMR vaccination may have caused autism and intestinal disorders in their children, I began to wonder. Upon looking at the records I discovered that my son had his MMR when he was 15 mo. & 26 days old and he was 17 months old when his allergies were diagnosed. He has never been able to eat many foods without problems since (19 years). I am personally convinced that the meltatonin and Sparx have helped in one area, but that the pig duodenum has made the huge difference which is allowing him to eat normally for the first time in his life.

This has all happened so quickly and is such an extreme that it is just hard to believe, even though it has happened in front of my own eyes! It’s a miracle for sure.

Thanks again for everything!

EMail-6 Sent: 1/26/01 6:43 AM To: krysalis@value.net

Dr. Gregg,

This is one heck of a discovery you’ve made isn’t it?

A monster has been created around here – A typical teenager has emerged. His sole topic is moving out of here and getting his own apartment. ha Can’t say that I blame him after being stuck here with us for so long. We’re trying to get him to slow down and stay at home at least for a while to see how he does, but the docile quiet guy that was either in bed, on his computer, or playing his guitar all these years is super-charged, self-assured, and ready to roll.

I’m anxiously waiting now to see if maybe his allergies will disappear too. Even though the breaking out and itching have improved somewhat since his use of prednisone began, they continue to bother him at times. If these symptoms go away also, it’s going to be miracle #2!!

I’ll keep you informed as time goes on. Thanks for all.

EMail-7 Sent: 1/26/01 11:53 AM To: krysalis@value.net

Hi again,

My son has been so busy having fun and being well that you haven’t heard from him yet.

Before taking this, he swore that if it worked he would get the word out everywhere. He just said to tell you he would be happy to write a testimonial for your web page but wants to give this all a little more test of time

I told you early on I was going to pressure cook all his foods from now on. Well, we actually never got to the pressure cooking part, but did try boiling the heck out of some noodles once. They were that chicken ramen stuff and he swore the chicken flavor in it did him in. That was just a few days after taking melatonin and he was still too sick to eat yet. I think someone else will have to try that theory because Mr. 19-yrar-old says he is finally able to eat anything he wants and sees no point in messing with the extra boiling. Can’t blame him. Just thought I’d relay this in case you were wondering.

It’s just as if he never had any problems. Too weird. It must feel great to have changed so many lives for the better! I guarantee you it’s wonderful being on the receiving end of it!

Heavy duty excitement here!!

EMail-8

I sent her an email suggesting that she take her son to see his doctor for a professional medical evaluation. This was her answer.

Sent: 1/28/01 5:43 PM To: David Gregg, krysalis@value.net

Dr. Gregg,

As for my son getting a medical evaluation, that will happen in time, but you’ll have to wait a little while. He is so fed up with seeing doctors that he’s not about to go to one unless he desperately needs to. But will inform you if he does. For now he is perfectly healthy and still feels great. His only remaining question is, “Will it last?” He says he doesn’t want to give false hope to anyone just in case it doesn’t.

My feeling is that this is for real and permanent. Time will tell. If he makes it through next Sept. through Dec., that will be the final proof. He has always gotten even worse every Fall since he was two years old! If that happens I’d say it would be book writing time for you.

Thanks again.

My Comments Concerning Motheralpha’s Emails.

This is an exciting result, far more dramatic than I had expected. However, I have done research for more than 40 years and have never seen a discovery that was optimized on the first day of discovery. This is an indication of great promise. However, it never turns out this easy. There will be reversals and additional actions will have to be identified to handle them. The direction has been identified, but the hard work of perfecting it has just begun. This hard work will take the involvement of a large group of people, all thinking and contributing with a willingness to share their experiences/discoveries. Lets hope this kicks off such a start. Its contribution is that it indicates a fairly clear direction that allows others to organize their investigations/efforts. History has shown that when this type of group effort get on its way, truly profound improvements are realized. However, it is everyone’s responsibility, not just motheralpha’s and mine.

I have some additional thoughts, projections & dreams:

1. Secretin vs. Prosecretin & infusions vs. pig duodenum: As I have discussed in my autism web page, prosecretin, the form of secretin stored in tissue, is the effective form and the pure hormone, secretin will be totally ineffective. Unfortunately, the medical community is still producing publications demonstrating the ineffectiveness of secretin, apparently not understanding this fundamental point.

Historically, the form of “secretin” that was effective in helping autism was extracted from pig duodenum and used in infusions (injected intravenously). I have been told that an analysis of this form showed it consisted almost entirely of the pure hormone secretin. However, it was still effective and human synthetic secretin, which contained no prosecretin was not. I thus conclude that the extraction process itself tended to break up prosecretin stored in the pig duodenum, producing mainly secretin. However, any good chemist knows such chemical reactions can never be total. There still had to be some prosecretin, if only in trace amounts. It was this trace amount that did the job.

If this theory is correct, then pig duodenum should be far more effective since essentially all of the “secretin” contained in the tissue would be in the form of prosecretin. Even though it is there in a very low concentration, it still could be in a greater concentration than that in the infusions. One would conclude that it not only would be the most effective way to obtain prosecretin, but also by far the least expensive. However, it would be hightly desirable that the people with the capability develop a synthetic version of human prosecretin for testing.

There is a question as to how well the prosecretin in pig duodenum survives the stomach acid. This is unknown. However, it brings up another interesting point. If the pig duodenum powder is mixed with the food, even if it is disassembled somewhat, producing some free secretin, the secretin will arrive at the duodenum when the stomach acid does, thus timed perfectly to trigger the pancreatic bicarbonate flush, as required.

2. Proposed Significance to Autism: (This falls into the class of a reasonable dream.) If we make the assumption that was made above, that one form of autism and one form of Crohn’s disease have the same cause, an adverse reaction to vaccinations, then one might project that this treatment should work equally well with that form of autism that has the same cause. If we also assume the major cause of autism is in fact the vaccinations, we now have a treatment that may stop the progression of autism. It is usually detected very early, 1-2 years old. I will make the very reasonable postulation that if treatment with pig duodenum is initiated as soon as it is detected, it may stop its progression and you will end up with a normal adult, not an autistic one. No such treatment exists today in any form, so this fills a total void.

3. Vaccinations: We all know the rather dramatic benefits that vaccinations have had on limiting/eliminating disease. They have become a sacred cow that tolerates no criticism. However there are many that claim to have evidence that that they can do considerable damage to a small fraction of the children and that the method of application needs a serious review. I am certainly no expert on the subject but I do have a few thoughts. In the first place, vaccinations inherently stress the system. They are designed to stimulate/stress the immune system, getting it to respond and in the process creating an immunity to a disease. Any stress to the system will always have a risk associated with it. All children are not the same. There will always be some who can not tolerate the stress and will react adversely. Unfortunately, it would appear that this adverse reaction can be very severe for some. I discussed this with Bernie Rimland and he told me some of the suspected adverse effects include autism, Crohn’s disease, asthma, allergies of all types, arthritis, ADHD and diabetes to name some. There is sufficient evidence to justify a systematic investigation of this. One of the aspects that I consider to be obvious is that it may be unwise to administer them together at the same time. Each will stress the immune system in its way. Combining them will only increase the total stress at the same time and introduce the possibility of overwhelming the child’s underdeveloped immune system, causing the damage. It would appear that they are administered together for economic reasons, and insufficient attention may have been given to the increased risk to the particularly vulnerable children. There is also a question as to how early in the child’s life they should be given. You certainly want to give them before it contracts the disease, but only after the child has a sufficiently developed immune system to deal with them. We are not talking about the majority of children. They seem to react well. We are talking about protecting the small fraction that is vulnerable to reacting adversely. We are also talking about establishing a protocol that still gets the essential job done, but much more safely for those children also.

4. Breast Feeding: A friend of mine at Lawrence Livermore National Laboratory brought up the point that as a baby first develops it depends greatly on the mother’s immune system to supplement its own underdeveloped one. This is obtained through Breast-feeding. If this were then connected to the vaccination question, it would be reasonable to assume there could be a large difference in response to vaccinations by breast-fed children Vs those who aren’t breast-fed. Those who aren’t breast-fed would be far more vulnerable to adverse reactions since their immune system will be less able to respond to the induced stress. Thus, one obvious action that could be taken is to vaccinate children that have not been breast-fed much later when their own immune system is more fully developed. When I brought this up to Motheralpha (above), she said she did not breast feed her son. Could this have been the reason he had such a bad reaction to his vaccinations? It is only one case, but the logic is quite good. It could also explain the growing increase in such problems since more and more mothers are working and are not breast-feeding.

5. Pig Duodenum – Beyond Prosecretin?: Consistent with the context of postulating, I wonder if the pig duodenum powder doesn’t go beyond providing the benefits of prosecretin. In Elaine Gottschall’s book “Breaking the Vicious Cycle” she presents a very scholarly analysis concluding that one extremely important cause of intestinal disorders is the lack of the enzymes in the intestinal wall that are necessary for breaking down disaccharides into monosaccharides, the only form that can be absorbed by the blood and used in metabolism. The pig duodenum powder, being derived from the intestine of the pig, even though it is only one part, is likely to contain those enzymes. If so, and if they are not destroyed in the stomach, and if the intestinal cells can absorb and use them (a lot of if’s), it will provide those enzymes to the intestine of the consumer, correcting such a problem if it exists. This might be part of the explaination of why “Motheralpha’s” son not only eliminated his Crohn’s disease, but was almost immediately able to eat a divesity of foods that he never could eat before. If this postulation is correct, then consuming the pig duodenum powder may turn out to solve the problem that the Gottschall diet is designed to solve, with no need for the restrictive diet. If so, one would expect it to be a superior approach in that it would also allow a greater diversity of diet, which, if used properly, could allow for greater improved health.

If this is true, it would lead one to the conclusion that it would be extremely difficult to produce a synthetic version of pig duodenum powder that would be as effective as the natural substance. It certainly would have to be more complex than prosecretin alone.

UPDATE, 2/14/01

DMSO More Effective than MSM? I have postulated in my health note on DMSO that it eventually comes into an equilibrium in the body with MSM. Thus it should make little difference which you take/start with. This has been a question that I have been asked numerous times and had no evidence as to the comparitive effectiveness of DMSO vs. MSM on Crohn’s disease. Along that line, I recently received the following email from a person who compared them on himself. His experiments are very early, but I thought his observations might be helpful to some.

Subject: RE: DMSO vs. MSM in treatment of Crohn’s, Sent: 2/11/20 5:33 AM

From: Jim Seidman, To: David Gregg, krysalis@value.net

Dr. Gregg -

I went ahead and tried DMSO. It’s only been a week, but the initial results are very promising. I wasn’t in too bad of shape to start with, since I’ve been on a variety of medications. But I still had trouble with frequent (but not constant) pain, diarrhea, and an inability to gain weight. Well, I’ve been using a mere 1/4 tsp. daily of a 65% dilution of DMSO, and I’ve already noticed a difference. My pain, while not gone, is much less frequent.

My diarrhea is gone. I’ve already gained 2 pounds, which is amazing. It took about 3 days before I really started noticing improvements, but now I feel a little better every day. That includes an increased energy level. Now, the interesting this is that 1/4 tsp. of a 65% DMSO solution should only have .77 mL (about 845 mg) of DMSO. As I mentioned, I’ve been taking MSM for several months with very little effect. I think it’s important to note that 845 mg of DMSO has had a rapid effect while 1500 mg of MSM has done so little. I’ll keep you posted on my progress, but I now think that oral administration of MSM is *not* equivalent in effect to dermal applications of DMSO. It may just be a matter of how well the substances are absorbed. However, people should be aware that a lack of results from MSM does not necessarily mean they won’t see results from DMSO. Thanks again for maintaining your very informative website.

- Jim Seidman

UPDATE, 2/21/01

Subject: Pig Duodenum Sent: 2/15/20 3:43 PM From: annette genovesi, cityheart@msn.com, To: krysalis@value.net

I can’t tell you how wonderful that pig duodenum has been both for myself and my autistic son, Adam. It has totally taken away all of his gastric upsets, which were considerable. As a result , he is so much calmer and happier. He has the fragile x syndrome , which is a genetic cause of his autism and mental retardation, so he has many different problems. The pig duodenum has totally alleviated a major physical one. I am ever so grateful. I myself have always had digestive upsets and problems. Now I find the duodenum really takes away ALL of the symptoms. Considering with my son, all of the expensive and time-consuming things I have tried over the years have been no help at all, so this is truly a miracle, as it works.

I thank you so much, and I thank my brother-in-law Robert Myers for introducing me to your site.

Sincerely, Annette Genovesi

UPDATE, 5/22/01 (Two emails from Mark)

Subject: Crohn’s, Sent: 5/17/20 2:21 PM From: Mark, Muscongas@triad.rr.com To: David Gregg, krysalis@krysalis.net

Dr. Gregg,

I read and reread your article (http://www.krysalis-sparx.com/crohn.html). What struck me initially was the title; it had the word “remedy” in it. I went to the health food store as soon as it opened this morning and purchased DMSO cream (70% DMSO) and melatonin (2.5mg). I applied the cream in my car in the parking lot of the health food store and popped a melatonin. I followed this by having a large slice of carbohydrate-filled pizza. I’ve been on the Gotschall diet now for a couple of weeks and have lost five pounds.I have no energy and no stamina.

The testimonials were impressive. I’m a lot like the folks that wrote. The frustration and hopelessness are the worst part. You never know what your day will bring.

My greatful thanks to you for being a bright guy and caring enough to dig into this. I don’t know if it will work for me but it’s given me something to hope for and I’m tired of being a downer.

Many thanks.

Mark.      PS: Don’t take melatonin and drive. I barely made it home and had an immediate two hour nap.

Subject: Re: Crohn’s, Sent: 5/18/01 From: Mark, Muscongas@triad.rr.com To: David Gregg, krysalis@krysalis.net

David,

I sit here amazed and it’s been less than 24 hours. As I mentioned, yesterday I started the morning with DMSO cream and a melatonin. That evening I again applied DMSO cream and took 2.5mg of melatonin before going to bed. I awoke early this morning, at about 4:30am and went to the bathroom. I had no pain but there was the usual blood. I went back to bed and got up again at 6:30am (my normal Sunday time). Again, I went to the bathroom although without the tremendous urgency which usually characterizes my attempts when I’m having a flare-up. There was no pain, no blood, no mucous. All was normal, by far the most normal in about three weeks.

I woke up my wife and told her I was cured. I am thrilled, relieved, amazed and eternally thankful I happened across your article. Crohn’s, ulcerative colitis, IBS, whatever you want to call it (my doctor has used all of them) is a debilitating disease. More than anything it becomes the primary driver of one’s day. I feel free.

I’m only on day one of my cure. Maybe I’m not cured. Many days lie ahead and we’ll see if this trend continues. Yes, with UC one day is a trend.

My thanks to you. You did good.

Mark.

Subject: Update, Sent: 7/25/01 From: Mark, Muscongas@triad.rr.com To: David Gregg, krysalis@value.net

Dear Dr. Gregg,

Just thought I’d let you know that after beginning use of DMSO cream twice per day my total healing time was six days. I have no symptoms; I’m completely healed. I’ve been in perfect intestinal shape for a couple of months now. I still use the DMSO cream twice a day mostly because I don’t dare not to. I was taking 2 Asacol tablets three times a day and have dropped to 1 Asacol tablet twice a day. Soon I’ll stop taking it.

DMSO has been a miracle. It’s a shame that GI doctors don’t include it in their recommendations for patients. There are a lot of people that could be helped and I’m telling as many folks as I know.

Many thanks.

Mark.

UPDATE, 12/10/01 Subject: It Works! Received: 11/28/01 11:01 AM From: Dan Jason, djason@pacbell.net To: dwgregg@krysalis.net

Dear Mr. Gregg,

I want to thank you for your research on Crohns. My daughter has had severe abdominal pain since she was a small child that continually got worse over the years, and reached a point that she was unable to go to high school. Due to pain she went to high school half of her freshman year, 2 months of her sophomore year and has not gone at all this year (her junior year). She has been on a home study program and has largely missed out on all of the normal social things high school kids do.

We have tried everything that medicine has to offer (and spent thousands). We started with local doctors who sent her Children’s Hospital. From there she was sent to Stanford. She has been scooped, x-rayed, had MRI’s, sent to pain management counseling, put on special diets, and given a variety of drugs. We even tried a Naturapathic doctor. She was diagnosed as I.B.S from one doctor, Colitis from another, and one even thought she might be in early stages of Crohns. Nothing they tried worked and we were told she would have to live with it. This weighed heavy on my heart, a parent who could do nothing to help his child.

Then I was told about your web site by an acquaintance and after reading your information and speaking to you I went out and immediately tried DMSO on my daughter. The results have been staggering! She has not had any pain to speak of, and when she feels anything coming on she puts DMSO on topiclly and it aborts the pain cycle. At first we thought it was too good to be true. It has now been six weeks and it still works! She can’t wait to go to high school her senior year. I am forever indebited to you for giving my daughter her life back. I now have her taking your sparx product to increase the overall health of her intestine and hopefully in time she will not have to use the DMSO at all.

Respectfully,

Dan Jason

UPDATE, 11/26/02 This is an email addressed not so much to me as to the readers of this web page.

Subject: More Success! Received: 11/23/02 12:36 PM From: Kim & Roy, hetzlerk@bellsouth.net To: dwgregg@krysalis.net

I believe that because of improvement in all three areas of CD, IC, and rosacea, in my case, all forms of inflammation, based on Dr. Gregg’s theories, that his research extends beyond the scope of improving intestinal health for CD sufferers. I believe that his research has revolutionized the way we should look at and treat acute and chronic inflammatory diseases not as an autoimmune response but from a biochemical standpoint.

I am 35 and was diagnosed with Crohn’s Disease (CD) at 18 with severe anemia. A few weeks ago I was diagnosed with Interstitial Cystitis (IC) after 3 years of bladder pain. I also have mild rosacea. During an acute CD attack a few weeks ago I read Dr. Gregg’s theories 2-3 times, made notes and read over the information again. It made sense to me that DMSO would help my CD and maybe the IC pain. Well, I applied the cream twice a day for the first two days and once a day thereafter. The first thing I noticed was decreased abdominal pain within 1 hour of application. The next morning the redness from rosacea had diminished significantly. My bladder pain was also reduced to a tolerable level.

I was excited and again reviewed the literature from Dr.Gregg’s site then purchased Melatonin. After the first night the difference was absolutely astounding! My abdominal pain was literally gone. Now, I am not one to believe in quick cures but the results spoke for themselves. I am now symptom free after less than two weeks of DMSO (1 tspn once a day) and Melatonin (3mg) at night. Here are several points from my experience affirming aspects of Dr. Gregg’s theories:

First, the “smell” generated from the use of DMSO was very strong initially but then disappeared after about a week. This suggests his theory that the smell diminishes with improved health holds true because as I felt better and time passed the smell was less noticeable.

Second, the idea that one “type” or cause of CD can kick off another. This comes from how both products helped me in an acute situation in very different ways.

Third, the idea of the importance of diet. Because I had been using diet to manage my disease for 5 years I looked into the carbohydrate specific diet and made even more changes. I also bought Acidophilus (which I had used before) to help with digestion. Both these changes have improved my intestinal health and helped the healing process.

Fourth, Dr. Gregg’s site was the first place I’d ever heard anyone speak of the “brain fog”. I too have been plagued by that very troubling symptom for some time and have been frustrated with my loss of ability to focus mentally the way I used to. This upsetting symptom has cleared considerably after just two weeks! I cannot wait to see how things are in another two weeks.

Fifth, my energy and appetite have increased dramatically. I have felt better and been more active than I have in a long time.

Sixth, and proof of number five. A few days ago I spent 7 hours each day for two days in a row raking leaves! The most amazing thing that I still cannot figure out is why my “allergies” are not bothering me. For years now I would have a sinus infection within 48 hours of that much yardwork and just feel miserable. Is this proof that DMSO also helps allergies?

Because so many people have had positive experiences as a result of Dr. Gregg’s research, controlled studies investigating the results of biochemically based treatments for inflammatory diseases and responses within the human body should be pursued further.

Thank you Dr. Gregg.

Best Regards,

Kim L. Hetzler M.Ed.

UPDATE, 5/11/04This is an email addressed not so much to me as to the readers of this web page.

Subject: Success with Ulcerative Colitis Received: May 11, 2004 From: Fred J. Fokkelman, (The Netherlands) Email: f.fokkelman@hccnet.nl To: dwgregg@krysalis.net

Now that I have used DMSO for about 3 weeks, for my Ulcerative Colitis, I feel things are really changing. What I thought to be another fake oil has become a true miracle product for me. Now my pain is almost gone and subsiding almost every day. The most important change is that I feel my intestines are starting to work normally again. For years I had diarrhea when I woke up in the morning or ate something afterwards. This was very annoying and unpleasant. But after visiting many doctors and taking many pills, DMSO has changed all this. My stools in the morning are normal and I can wait without running to the toilet. I can advise everybody to try DMSO because it might change their lives for good. I will now use it oonly when I feel an inflammation coming up as a last resort measure. The feeling that I have this product does make me feel more confident and secure. At last I have found something to beat my Ulcerative Colitis.

UPDATE (email), 9/15/06

Dear Dr.Gregg,

I know you must get hundreds of letters like this, but I wanted to express my gratitude for literally saving my life with your web site. Like your friend Barbara, I too have been plagued with Crohn’s Disease for all of my adult life. At age 27, I had 15 inches of my intestines removed and now at age 60 was considering even more drastic surgery that would have been life altering in terms of my quality of life. The connection of my old incision had narrowed so much and new disease was found on the other side that the surgeon was planning to remove the whole large intestine between the right and left sides. Needless to say, I was not looking forward to the prospect of two surgeries and having liquid stools 6-10 times a day for the rest of my life, which is what they predicted.

I decided to do an Internet search on alternative treatments for Crohn’s and landed on your site first. I was impressed with what you said and it made sense to me. The one sentence that really stuck out in my mind was the one that said DMSO and MSM are basically the same, one leading to the other. The health food store that I frequent had already recommended that I use MSM with my glucosamine for arthritis, so I already had it, but was not taking as much of it as the bottle recommended. I also had not made the connection between my Crohn’s pain and the MSM. It has worked like a charm!!! I have never felt this good in my entire life! If I start to feel a little twinge of pain or discomfort, taking an MSM soon relieves it. Other benefits are that I am no longer bloated or gassy. I’m not sure if that is the effect of the MSM or that I also started taking acidophilus on a regular basis at the same time.

I have sent your web address to all my friends as well as to my doctors. You have changed so many lives without realizing it. I can’t thank you enough for your humanitarian effort and giving me my life back! I have not tried the DMSO because the MSM seems to be working just fine. I did buy the Melatonin, although I’m not sure how much to take. The health food store said that since it is a hormone, it should not be used every day. What is your feeling since I am not using it as a sleep aid?

Please continue to publish your findings on this and other debilitating illnesses. You are such a wealth of information and your approach as a chemist has been so enlightening. You have made a complicated subject easy for the layperson to understand. Thank you for taking the time to publish you findings on the Internet so that others like me can benefit.

Very truly yours,

Sharon

This Is For Information Only. It Represents The Observations, Views And Opinions Of The Authors, But Is Not A Recommendation For Treatment. Anyone Reading It Should Consult His/Her Physician Before Considering Treatment.

Barbara DeMarco Livermore, CA Ph: (925) 449-1128

I have had Crohn’s Disease for more than 30 years. Attempts to control my disease with conventional treatments using steroids and sulfa drugs, have provided some help, but my disease still progressed to where I had to have many surgeries, which eventually lead to an ileostomy. The conventional drugs and surgeries slowed the progression of the disease but did not stop it.

In February, 1995, a friend and coworker, Dr. David Gregg decided to see if he could find/invent something that might help me. My bowel was inflamed and I was working half time. Dr. Gregg did a literature search and an analysis of what he thought might be the cause of CD. He concluded that DMSO might help. Having had horses, I was quite familiar with DMSO’s use on animals. Because of this I felt it was safe to try. I consulted my doctor and he thought it would be safe also. During this time I was only physically able to work in the morning. At noon, after consulting with my gastroenterologist, I purchased some DMSO at the local health food store and applied approximately 1-2 teaspoons full on my abdomen (it absorbs directly though the skin). I then went to a movie. Within an hour, almost all of my abdominal pain was gone. There was still residual intestinal damage so it took approximately one month for the healing process to complete, with the termination of all abdominal pain. During this time I continued to apply DMSO two to three times a day, often changing skin area to minimize irritation on one patch of skin. I did not limit application to my abdomen. I found using a gel form of the DMSO, which was 70%, DMSO and 30% water to cause less irritation and to be easier to apply.

It has now been more than three years and DMSO has kept my CD in control during this time without the need for any other treatments, drugs or surgeries. I have had numerous times when I felt the familiar onset of CD inflammation and DMSO always stopped its progression. However, this would not necessarily take one hour, but sometimes took anywhere from two days to a week, applying the DMSO approximately three times a day. Since my CD never progressed to further inflammation, I have to conclude that the DMSO was acting not just a pain block, but it stopped the progression of my CD itself.

One of the beauties of the DMSO is that it works so fast and is so totally effective. It does not have to be used in a preventative mode. DMSO only needs to be used at the onset of inflammation. I have experienced no negative side effects. I have also focused on good diet and supplements to extend my periods of remission. Amazingly, this process has worked so well that I have had to use the DMSO only twice in the past year.

My experience with the DMSO approach to treating Crohn’s Disease has been the true miracle I had been hoping for. What is also strange is that DMSO is so easily available and so absurdly inexpensive. Don’t let the simplicity and low cost of this approach deceive you into thinking it is ineffective or only moderately effective. As a severe CD sufferer, I find DMSO profoundly effective. DMSO has made it possible for me to lead a normal life. I am writing this testimonial because I can only hope DMSO will be found to be effective in helping other CD sufferers.

Barbara

Pete ,Modesto, CA

From June 1977 to about March 1994, I was hospitalized from two to as many as seven times per year with severe flare-ups of Crohn’s disease, with all of the usual symptoms of extreme diarrhea, cramping and weight loss.

In 1994, I started taking melatonin (3-6 mg/day, taken in the evening) and drinking green tea with one tablespoon of apple cider vinegar and one tablespoon of raw honey each day. I am very pleased with the results. I have not had a flare-up of Crohn’s colitis in over three years. I have returned to my normal weight, after being underweight for years.

Pete

Lori Daniello P.O. Box 9316-C Napa, CA 94558 Ph: (707) 864-2275

September 1998

I have suffered with Crohn’s Disease for 10 years. I used the standard treatments of steroids and sulfa drugs prescribed by my doctor, with unsatisfactory results. Neither of these drugs stopped the pain or progression of my disease. After years of use, all the negative side-effects from these prescription drugs began to out-weigh the benefits for me and I refused to take them anymore.

A year ago my aunt told me about David Gregg’s experience and write-up on using DMSO and/or Melatonin for helping Crohn’s Disease. I had almost lost all hope of ever getting any relief from this horrible disease. Needless to say, I didn’t hesitate trying it. It’s inexpensive to by at any health food store, is simple to use, and it’s effectiveness is astonishing. The only side effect I found was an odor on my breath. Because of other complications, I also used a vegetarian enzyme complex to help with digestion.

I started out using one or two teaspoons of DMSO on my skin whenever I felt pain or discomfort. After just four days the results were amazing. My pain and discomfort would stop 20 or 30 minutes after applying DMSO. My appetite came back. I was gaining a little weight, and my energy level began to rise. I felt great.

I was so impressed and amazed with the results I contacted Mr. Gregg and told him how well his treatment theory was working for me, and that I thought his theory was going to change my life. It has definitely changed my life. I have been in remission for months.

After using DMSO to get my pain and inflammation under control, I began to use 3 to 6 mg of melatonin nightly, which I still use every night. I have been in remission and free of any symptoms for months now. I feel better than I have in 10 years, and finally live a normal life again.

I would hope that writing this testimonial helps others who suffer from CD to know that there is profoundly effective and affordable help for our painful condition.

Lori

Rose Forrest, Danville, CA

September, 1998

Approximately thirty-five years ago when I started to have children, I developed an abdominal pain in a particular spot that remained a part of my life up to approximately two years ago, when I met David Gregg. The pain varied in intensity throughout those years, but it was always there. At first it was misdiagnosed as being due to scar tissue in the intestine, which was surgically removed. The pain came back anyway. Then it was then thought to be due to a kidney problem because I once had kidney surgery for kidney stones. (I later learned that kidney stones are frequently associated with Crohn’s Disease.) In 1980 I moved to California and still had a lot of symptoms consisting of continued abdominal pain in that particular spot and a continuation of problems with kidney stones. I had two kidney surgeries and passed 16 kidney stones. I was working in a doctor’s office and decided to see a new doctor, a gastroenterologist, who had a particularly good reputation. After treating me for a while and not being certain what was causing my problems, he decided to make a heroic effort to try to find out what was going on. He put me in the hospital and viewed my intestine with a scope. He saw what he thought was a polyp, but when he tried to excise it, it “exploded” and underneath he saw what he knew to be Crohn’s Disease. He took a biopsy which confirmed it was Crohn’s Disease. Thereafter I started using all the standard prescription drugs for CD. They did help, and were better than nothing, but they were only partially effective in eliminating the pain and had unpleasant side effects. I continued this up to approximately two years ago when I met David Gregg in my aerobics class at my health club.

I was talking to him one morning and he told me he thought he might have discovered something that would greatly help Crohn’s Disease. I told him I had CD and was interested. He then gave me a copy of a document he had written describing the successes achieved with DMSO and Melatonin on both Crohn’s Disease and Ulcerative Colitis. I decided to try it and got some of both at my health food store. I applied approximately a tablespoon of 99.9% liquid DMSO to my abdomen and in about two hours, I felt a very large reduction in abdominal pain, specifically including that particular spot associated with my disease. I continued to apply it once-a-day for the following 3-4 days and the pain totally vanished. I initially used a cotton swab to apply it, but later decided that using a glass bottle with an eyedropper would be easier and better. During the following year, I stopped using all my prescription drugs and used the DMSO only. In that year I had approximately four reoccurrences of pain, which were totally stopped using the DMSO, one tablespoon full applied to my abdomen, once-a-day for 3-5 days. The thing that was specially unique was that between these “attacks” I felt totally free of pain – for the first time in over 35 years. This last year, the second year of DMSO use, I have had to use it only once and the one event of inflammation pain was much less severe. Again, I am now completely free of the very familiar abdominal pain associated with my CD.

For me, it appears that the DMSO not only stopped my inflammations, but may be leading me to a more permanent cure for my disease. Only time will tell. With the DMSO being so successful, I did not attempt to use the Melatonin approach.

I can’t adequately express how much this has benefited the quality of my life. I am thus writing this testimonial in the hope it will help others suffering from this horrible disease in the same way it helped me.

Rose

 

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