How does hydrazine sulfate work to block enzymes, thus enabling cancer cells to be shrunk?

Working Summary: Gold did something clever: He just blocked a single liver enzyme from working—and that caused the cancer to die from starvation! The substance he used is still available.

You will recall Dr. Koch’s work in the 1920s.He had discovered that sugar oxidation was a key factor in cancer formation. He worked on the premise that, if the sugars could be oxidized, the cancer would be reduced. More oxygen was needed at the site of the tumor, in order to eliminate it.

Then we noted Dr. Warburg’s work in 1930. He came upon the same principle, and expanded on it. Warburg recognized that a key was to get more oxygen to the cancer cell. Warburg had found that normal cells require oxygen in order to live, but cancer cells die in the presence of oxygen.

In 1968, Dr. Joseph Gold, of Syracuse, New York, published a scientific paper in which he proposed new departure for cancer chemotherapy (Joseph Gold, “Proposed Treatment of Cancer by Inhibition of Gluconeogenesis,” Oncology, 22:185-Specific Systems of Treatment 207, 1968).

Gold’s theory was the antithesis of accepted medical principles. Surgery and radiation had ruled for decades; but, in the 1950s, high-priced cancer drugs entered the picture more than ever before. By the late 1960s, it was becoming obvious to thoughtful practitioners and researchers that the physical damage by chemical toxicity was as great as that caused by surgical cutting and radiation therapy.

Chemotherapy was keyed to placing high toxicity—poison, if you will—at the site of the cancer,in order to kill it. But, in the process, the entire system was greatly weakened, sometimes without recovering.

In contrast, Gold suggested that, instead of trying to kill the cancer cell, we need only block its ability to injure other cells.Gold had studied the work of Otto Warburg,and his theory of the nature of cancer cell metabolism.

According to Warburg, all cancer cells live by fermenting sugar in what are essentially“airless” (anaerobic) reactions. Find a way of stopping this fermentation, and you will be able to stop the cancer.

Later, in the 1950s, Dr. Dean Burk and associates at the National Cancer Institute had delved into Warburg’s contribution. Burk won a scientific prize for demonstrating that Warburg was correct in his views about cancer ferments. (However,it was also discovered that, although rarely,cancer cells do use oxygen respiration; and, occasionally,some normal cells have fermenting mechanisms.)

For a short time, oxalic acid (which blocked fermentation) was tried as a cancer remedy, but it failed. Like regular chemotherapy, it was so toxic that it injured regular cells as much as cancer cells.

With all this information in hand, Joseph Gold went beyond either Warburg or Burk. He developed an enlarged theory:

A primary cause of death from cancer is the weight loss and debilitation which occurs. The medical name for this is cachexia. But why does it occur? If it could somehow to interrupted, the disease could be brought under control.

But what causes cachexia? Why is the cancer patient reduced to skin and bones while his tumor grows vigorously? Orthodox medical theory had no answer to this. Here was Gold’s theory:

Cachexia is the result of cancer’s ability to“recycle its wastes.” But it does this by overloading the body with the task of trying to discharge those wastes. The resultant energy drain results in emaciation.

So far, this theory closely paralleled aspects of the Gerson theory. But, while the Gerson theory held that it was the toxic wastes introduced into the body through bad living, diet, etc., which induced cachexia, pain, and death from liver overload, Gold attributed the problem solely to an excess of lactic acid:While regular cells use oxygen for energy,cancer uses glucose (sugar) as the fuel. But the result is fermentation. The sugar only partially metabolizes, or combusts. The waste product,which is lactic acid, is ejected by the cancer cells and carried by the blood to the liver and kidneys. But lactic acid is not simply expelled from the body. Instead, it is reconverted in the liver back into glucose. But the body must now expend a great amount of energy doing this.

The glucose is then poured into the blood stream, and picked up by the cancer cells—and used as still more fuel! The vicious cycle broadens and deepens.

“The net result is a loss of energy from normal body energy ‘pools.’ As the cancer grows,its production of lactic acid grows, imposing on the body a condition in which the normal body energy ‘pools’ become more and more depleted.”—Joseph Gold, Cancer Research Institute,Informational Brochure, 1979.

Eventually rapid weight loss and debility results—cachexia.

“Cachexia is but the end result of an insidious process—unrecognizable at first, but slowly taking its toll of the body’s reserves until a ‘point of no return’ is reached. Cachexia begins with the very first cancer tissue. What we need is a way to stop the vicious cycle and thereby put a halt to the leading cause of death in cancer:cachexia.”—Joseph Gold, “Proposed Treatment of Cancer by Inhibition of Gluconeogenesis,”Oncology, 22:185-207, 1968.

So far, Gold’s research was fully approved by the powers that be, for it was in the realm of theory.But then he set to work in search of a substance which could block this interaction between the liver and the cancer cells. Trying one thing and then another (including the amino acid tryptophane),everything seemed to fail.

Then, in the early 1970s, Gold read a research paper which stated that hydrazine sulfate had the ability to block a key enzyme in the liver—which allowed lactic acid to be converted into glucose.

First, Gold tried hydrazine sulfate on four different transplantable tumor systems in animals.It seemed to work fairly well, and supported Gold’s theory. Cancer cells in the test tube were not injured, but in the body were destroyed. Therefore an indirect mechanism was involved. Further examination revealed that the cancer cells were not directly poisoned.

Gold also found that hydrazine sulfate could be used to increase the effectiveness of regular cell poisoning drugs (chemotherapy) in animals. Perhaps best of all, if only small amounts were used, the chemical compound did its work without poisoning the normal cells. It is in no way a killer cell of any kind—including malignant ones. It only works by blocking a certain liver enzyme, needed to provide energy to the metabolism of the tumor.

In 1973, Gold published his first report on his findings, and then gave a talk about it at the New York Academy of Sciences. Afterward, a physician came up and asked for further data on how to dispense it, since he had a woman cancer patient who, within three or four days, would be dead.

Within a few weeks, the woman was dramatically improved, and on her feet again. A number of other patients also experienced improvement.

By August 1973, 20 or 30 patients were taking it in various parts of the country. By October, there were over a thousand.

Gold began to experience difficulties in his requests for further funds from NCI for research.But Dr. Dean Burk was still at NCI. He it was who had himself amplified somewhat on the work of Warburg. Gold’s findings vindicated both Warburg and Burk’s research into cancer cell metabolism.

Burk was enthusiastic, and said so. He released this memorandum to the scientific community in mid-1973:

“Since April 1, 1973, upwards of 30 cachetic or ‘terminal’ cancer patients have been treated with gelatin capsules containing 60 mg of hydrazine sulfate three to four times a day (at intervals of about 6 hours). Usually within 24-48 hours there is a marked return of appetite followed by continued increase in weight, remarkably restored physical activity, and eventually decrease in tumor size, decrease in pain, and related decrease in symptomatology.”—Dean Burk, Memorandum, Department of Health,Education, and Welfare, National Institutes of Health, August 10, 1973.

About six months later, Burk wrote:“[Hydrazine sulfate is] the most remarkable anti-cancer agent I have come across in my forty-five years of experience in cancer . . It would make little difference with hydrazine sulfate if the FDA wanted to balk, because this material is so cheap—and it is cheap because it is made by the trainload for industrial purposes.”—Dean Burk, “New Approaches to Cancer Therapy,” New England Natural Food Association Bulletin, Spring 1974.

In a paper on the subject, presented before top officials at Sloan-Kettering Institute in New York, Burk said this:

“Let me tell you this perfectly true story . . I could give you many. A woman with Hodgkin’s disease who had been flat on her back for seven weeks, who had no appetite and who had lost all her weight—a ‘paper-thin’ patient—took hydrazine sulfate. One week later she was shopping in the grocery store with her own bag; five day later she was spending most of the day inher garden. I don’t give that as any miraculous story—it is simply the plain truth.”—Ibid.

Hydrazine sulfate, because it was a chemical,was immediately put into clinical trials by the chemotherapy department at Sloan-Kettering. Since it had already been tried on humans, and since news of it was so widespread among physicians and somewhat among the general public, announcement was made in September that a joint SKI-Syracuse Cancer Research Institute study would begin.

But, following that announcement, officials at SKI immediately drew back, and their participation was only deleterious. Patients who died before receiving even one dose were listed as “failures.”

Instead of receiving the optimal dosage (which was 60 milligrams of hydrazine sulfate for the first three days, 60 milligrams twice a day for the next three days, and 60 milligrams three times a day thereafter), SKI had them start with 1 milligram a day for the first day, 2 for the second, etc., until they reached 20 or 30 milligrams a day.

When Gold appealed to them to abide by the original dosage agreement, SKI ordered a single massive dose of 120-190 mg. to be given. This high dosage was toxic in the extreme, and eliminated all earlier improvements. According to Gold, the SKI chemotherapist told a relative of one of the patients that he had no ”enthusiasm or interest in” hydrazine sulfate and that it was “worthless” in the treatment of cancer (ibid.).

In the summer of 1974, Gold told a packed audience at a National Health Federation convention about the benefits of hydrazine sulfate. This caused the news about the compound to travel even farther.In response, the FDA issued a directive blocking access to the compound by physicians and making it illegal for chemical companies to sell hydrazine sulfate directly to the public.

That announcement was immediately preceded by an official statement issued by the public affairs department of SKI:

“(1) None of these patients responded positively to hydrazine sulfate, and

(2) some of the patients developed neurotoxicity [nerve damage],apparently due to the administration of this drug.“Based on these findings, therefore, Sloan-Kettering Institute is no longer treating patients with hydrazine sulfate, nor are we conducting any further experiments with it at the present time.”—SKI Statement, July 25, 1974.

Calbiochem, Inc., a California drug company which had been interested in marketing it, immediately drew back, correctly declaring, that hydrazine sulfate was in the public domain and thus unpatentable. In other words, like goldenseal,chaparral, apricot kernels, pau d’arco tea, and vitamin C, there were no big profits to be made from it. “We saw absolutely no place to go with it,” he said (David M. Rorvik, “Who Wrote the American Cancer Society’s Denunciation of Hydrazine Sulfate” Alicia Patterson Foundation Newsletter, New York, November 29, 1976).

In March 1976, the American Cancer Society placed the substance on its list of unproved methods.In early 1979, NCI invited Dr. Michael L. Gershanovich, director of medical oncology, Petrov Research Institute of Oncology, Leningrad, to come to the United States and describe his four-year study of 225 patients on hydrazine sulfate.

But, after arriving in America, Gershanovich was suddenly denied permission to speak at the May 1979 New Orleans meeting of the American Association for Cancer Research. However, the mistake had not been caught early enough, and abstracts(a summary) of Gershanovich’s planned talk were printed as abstract #969 in the Proceedings of the AACR.

From 1984 to 1990 and beyond, Rowan T.Chlebowski, M.D., Ph.D., and his associates at UCLA in Los Angeles began publishing a series of reports documenting the ability of hydrazine sulfate to prevent weight loss in cancer.They found that critically ill patients showed only marginal response, but those in better condition when the treatment was started did better.

After a year of treatment, 42% of those taking hydrazine sulfate were alive, compared to 18% of those who did not receive it.The use of this compound helps patients feel better within two or three weeks. But it occasionally can have mild side effects, including mild numbness of the fingers and toes, nausea, vomiting,and slight drowsiness. Gold found that thiscould be reduced or eliminated by taking vitamin B6.

While crude hydrazine sulfate can be toxic,the form used in cancer treatment differs from industrial grade versions in that it has been highly purified.

Hydrazine sulfate has been shown to be a useful chemical compound in eliminating cancer tissue.It reduces lean tissue wasting (cachexia)and improves the abnormal glucose and insulin levels common among cancer patients.

The normal dosage is one 60-mg tablet, taken three times a day. One hundred 60-mg tablets,enough for a month’s supply, costs about $25.Although not permitted to be sold in the U.S.,it can be ordered from overseas companies by mail order, or from Mexican clinics using it (such as Hospital Santa Monica, 4100 Bonita Road, Bonita,CA 91910 Ph: (800) 359-6547 / (619) 428-1147)

Dr. Gold discovered Hydrazine Sulphate was the means to reverse cachexia. He and 2000+ other Doctors treated thousands of cancer patients with Hydrazine Sulphate blocking gluconeogenesis without blocking normal energy metabolism, thus overcoming cachexia and reversing cachexia-dependent tumor progression.


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